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What are terpenes in cannabis?

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  • Also asked
  • What do terpenes do?
  • Terpenes meaning
  • Why does weed smell?
  • What are the main terpene profiles in cannabis?
  • Does irradiation destroy terpenes?

Short answer

Terpenes are the volatile compounds that give cannabis most of its smell and taste: myrcene, limonene, β-caryophyllene, pinene, terpinolene and many more. The plant makes them in its glandular trichomes, alongside cannabinoids. Total terpenes average about 2% of flower weight. Established chemistry.

Why

Terpenes are made in the resin glands. Terpene synthase enzymes in the trichomes build monoterpenes (10 carbons, lighter and more volatile) and sesquiterpenes (15 carbons, heavier) from shared precursors [1]. Which synthase genes a plant carries largely sets its profile [1][5].

Commercial flower clusters into a few profiles. In 89,923 US lab results, THC-dominant flower fell into three terpene groups: caryophyllene–limonene, myrcene–pinene and terpinolene–myrcene, with the first two holding 87.4% of samples [2].

Not every smell is a terpene. The fuel-like "gas" note comes mostly from trace prenylated sulfur compounds, detected at tiny levels [3].

Terpenes are fragile. Monoterpenes evaporate and oxidise with heat, air and time. Gamma irradiation cut some volatile monoterpenes by 10–20%, up to 38% for one compound [4]; slow drying and cool, dark, airtight storage keep more.

Labels track terpenes loosely. "Indica" and "sativa" tags associate with a few terpenes, not with genome-wide ancestry [5].

The numbers

Terpene Class Common aroma
Myrcene Monoterpene Earthy, musky
Limonene Monoterpene Citrus
α- and β-pinene Monoterpene Pine
Terpinolene Monoterpene Fresh, herbal, "haze"
β-caryophyllene Sesquiterpene Pepper, spice
Humulene Sesquiterpene Woody, hoppy
Total terpenes — ~2% of flower weight on average

What to do

  1. Read the terpene section of a certificate of analysis, not just THC.
  2. Dry slowly, about 18–21 °C (64–70 °F) and 55–62% RH for 7–14 days.
  3. Cure and store in full, airtight, dark jars; skip humidity packs, which rob terpenes.
  4. Pheno-hunt by nose and keep unusual profiles.

Common mistakes

  • Assuming a terpene predicts an effect. Effects are reported, not promised.
  • Fast, warm drying that drives off monoterpenes.
  • Believing very high total-terpene claims without a lab name and date.

Follow-up questions

What are the main terpene profiles in cannabis?

The main terpene profiles in commercial THC-dominant cannabis are three groups found in a 2022 study of US lab data: caryophyllene–limonene, myrcene–pinene and terpinolene–myrcene. The first two held 87.4% of samples, and terpinolene-led flower was the smallest group. Rarer dominants include ocimene and the sesquiterpene alcohols guaiol and eudesmols.

Does irradiation destroy terpenes?

Irradiation does not destroy terpenes, but it can reduce them. Some studies found no significant terpene change, while others measured 10–20% losses of volatile monoterpenes such as myrcene, ocimene and terpinolene, up to 38% for one compound, with sesquiterpenes barely changing. In one study, months of normal storage cost more terpenes than the treatment did.

Do terpenes change the effects of cannabis?

Whether terpenes change the effects of cannabis is not settled. Aroma is linked with reported subjective effects in some consumer studies, and 'indica' and 'sativa' labels track only a few terpenes, not effects. No controlled evidence shows a given terpene reliably produces a given effect, so treat terpene-based effect claims as reported experience, not a promise.

Sources

  1. Booth JK, Bohlmann J. 2019. Terpenes in Cannabis sativa – From plant genome to humans. Plant Science 284:67-72. doi.org/10.1016/j.plantsci.2019.03.022
  2. Smith CJ, Vergara D, Keegan B, Jikomes N. 2022. The phytochemical diversity of commercial Cannabis in the United States. PLOS ONE 17(5):e0267498. doi.org/10.1371/journal.pone.0267498
  3. Oswald IWH, Ojeda MA, Pobanz RJ, et al. 2021. Identification of a new family of prenylated volatile sulfur compounds in cannabis revealed by comprehensive two-dimensional gas chromatography. ACS Omega 6(47):31667-31676. doi.org/10.1021/acsomega.1c04196
  4. Hazekamp A. 2016. Evaluating the effects of gamma-irradiation for decontamination of medicinal cannabis. Frontiers in Pharmacology 7:108. doi.org/10.3389/fphar.2016.00108
  5. Watts S, McElroy M, Migicovsky Z, et al. 2021. Cannabis labelling is associated with genetic variation in terpene synthase genes. Nature Plants 7:1330-1334. doi.org/10.1038/s41477-021-01003-y

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