GenetixBayEST. 2009
Glossary · Cannabinoids and terpenes

Beta-caryophyllene

Beta-caryophyllene is a spicy, peppery sesquiterpene common in cannabis, notable as a dietary terpene that also binds the CB2 receptor in laboratory studies.

Also written β-caryophyllenecaryophylleneBCPtrans-caryophyllenecarophyllene

EstablishedDraft: awaiting expert reviewUpdated

Beta-caryophyllene (BCP) is a bicyclic sesquiterpene found in black pepper, cloves, hops and many cannabis cultivars. It smells spicy, woody and peppery. It is one of the most common dominant terpenes in commercial flower and usually travels with alpha-humulene, which is made by the same family of enzymes.

In practice

Readings of 0.2-0.8% w/w are common in flower. As a sesquiterpene it is less volatile than the monoterpenes, so its share of the total often rises in stored material. In air it slowly oxidises to caryophyllene oxide. Lab studies have shown it binds CB2 receptors, which made it famous. That's a pharmacology finding, not a promise of any effect from smoking a flower, and GenetixBay makes no health claims.

Don't confuse with

  • Caryophyllene oxide: the oxidised derivative, less aromatic.
  • Humulene: its isomeric partner, woodier and earthier.
  • Alpha-caryophyllene: an older name for humulene, a source of confusion.

Related terms

Sources

  1. Booth JK, Bohlmann J. 2019. Terpenes in Cannabis sativa: from plant genome to humans. Plant Science 284:67-72..
  2. Smith CJ, Vergara D, Keegan B, Jikomes N. 2022. The phytochemical diversity of commercial Cannabis in the United States. PLOS ONE 17(5):e0267498. doi.org/10.1371/journal.pone.0267498
  3. Russo EB. 2011. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology 163(7):1344-1364. doi.org/10.1111/j.1476-5381.2011.01238.x
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