GenetixBayEST. 2009
Glossary · Genetics and breeding

Codominant

Codominance is when both alleles at a locus show in a heterozygous plant, as with THCA and CBDA synthase, so a B_T/B_D plant makes both THC and CBD.

Also written codominanceco-dominantco-dominanceincomplete dominance

EstablishedDraft: awaiting expert reviewUpdated

Two alleles are codominant when a heterozygous plant expresses both of them rather than one masking the other. Incomplete dominance is a close relative: the heterozygote is intermediate between the two homozygotes. Growers usually lump the two together.

In practice

The cannabinoid synthase locus is the standard cannabis case. In de Meijer's model, B_T codes for THCA synthase and B_D for CBDA synthase. B_T/B_T plants are THC-dominant (chemotype I), B_D/B_D plants CBD-dominant (chemotype III), and B_T/B_D plants make both, typically in a ratio near 1:1 (chemotype II) (de Meijer et al. 2003).

This has a direct breeding consequence. Cross two balanced 1:1 plants and the offspring segregate about 1 THC-dominant : 2 balanced : 1 CBD-dominant. A "1:1 seed line" cannot be fixed by selection alone, because the balanced type is the heterozygote. The stable route is to cross a THC-dominant and a CBD-dominant parent, which gives uniform balanced F1s.

Units and formula

Expected offspring of B_T/B_D × B_T/B_D: 25% B_T/B_T, 50% B_T/B_D, 25% B_D/B_D. Real ratios vary because the region also contains duplicated and non-functional synthase copies (Laverty et al. 2019).

Don't confuse with

  • Dominant: one allele masks the other; in codominance neither is hidden.
  • Ratio inheritance: the exact THC:CBD ratio within balanced plants still varies with other genes and environment.

Related terms

Sources

  1. de Meijer EPM, Bagatta M, Carboni A, et al. 2003. The inheritance of chemical phenotype in Cannabis sativa L. Genetics 163(1):335-346. doi.org/10.1093/genetics/163.1.335
  2. Laverty KU, Stout JM, Sullivan MJ, et al. 2019. A physical and genetic map of Cannabis sativa identifies extensive rearrangements at the THC/CBD acid synthase loci. Genome Research 29(1):146-156. doi.org/10.1101/gr.242594.118
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